Disclaimer to the Online Edition
This Manual has been designed for use in the NICU at London Health Sciences Centre (LHSC), London, Ontario, Canada, and represents clinical practice at this institution. The information contained within the Manual may not be applicable to other centres. If users of this Manual are not familiar with a drug, it is recommended that the official monograph be consulted before it is prescribed and administered. Any user of this information is advised that the contributors, Editor and LHSC are not responsible for any errors or omissions, and / or any consequences arising from the use of the information in this Manual.
cosyntropin
Indication
- ACTH stimulation test: Diagnosis of adrenocortical insufficiency (differentiates primary adrenal from secondary (pituitary) adrenocortical insufficiency)
- Used in the diagnosis of congenital adrenal hyperplasia
Dosage Guidelines
- ACTH stimulation test: 30-35 microgram/kg/dose IV x 1 (Maximum dose 250 micrograms)
Administration
- IV direct given slowly over 3-5 minutes
- Reconstitution: add 1 mL NS to 250 microgram vial (Final concentration = 250 microgram/mL)
- Discard unused portion of the vial after use
Comments
- Required bloodwork as per PAED ENDO Adrenocorticotropic (ACTH). Neonate PowerPlan includes ACTH, glucose, electrolytes and cortisol prior to dose (Time 0), followed by cortisol levels drawn at 30 minutes and 60 minutes post cosyntropin dose
- Send ACTH (200 microliter) in a lavender top microtainer on ice to the Lab
Supplied As
- 250 microgram/mL vial for injection
References
Lexi Sick Kids, Lexi Peds