Disclaimer to the Online Edition
This Manual has been designed for use in the NICU at London Health Sciences Centre (LHSC), London, Ontario, Canada, and represents clinical practice at this institution. The information contained within the Manual may not be applicable to other centres. If users of this Manual are not familiar with a drug, it is recommended that the official monograph be consulted before it is prescribed and administered. Any user of this information is advised that the contributors, Editor and LHSC are not responsible for any errors or omissions, and / or any consequences arising from the use of the information in this Manual.
domperidone
Indication
- Prokinetic Agent
- Treatment of esophageal reflux and/or gastrointestinal stasis through promotion of gut motility
Dosage Guidelines
- 0.3-0.6 mg/kg/dose orally TID to QID
- Maximum total daily dose is 2.4 mg/kg
Administration
- Oral
- Give 15 minutes prior to feeds
Adverse Effects
- Usually well tolerated at recommended doses
- Rarely, can cause irritability, lethargy, acute dystonic reactions (involuntary twisting or turning of the neck, tension or twisting in arm or leg, uncontrolled rapid blinking, drooling or difficulty swallowing)
Comments
- Contraindicated in infants with pre-existing gastrointestinal hemorrhage, perforation or obstruction
- Extend interval to once or twice daily in patients with renal impairment
Supplied As
- 5 mg/mL oral suspension
References
LexiComp Sick Kids