domperidone
Indication
- Prokinetic Agent
- Treatment of esophageal reflux and/or gastrointestinal stasis through promotion of gut motility
Dosage Guidelines
- 0.3-0.6 mg/kg/dose orally TID to QID
- Maximum total daily dose is 2.4 mg/kg
Administration
- Oral
- Give 15 minutes prior to feeds
Adverse Effects
- Usually well tolerated at recommended doses
- Rarely, can cause irritability, lethargy, acute dystonic reactions (involuntary twisting or turning of the neck, tension or twisting in arm or leg, uncontrolled rapid blinking, drooling or difficulty swallowing)
Comments
- Contraindicated in infants with pre-existing gastrointestinal hemorrhage, perforation or obstruction
- Extend interval to once or twice daily in patients with renal impairment
Supplied As
- 5 mg/mL oral suspension
References
LexiComp Sick Kids