famotidine

famotidine

Indication

• Histamine H2-receptor blocking agent used in the prevention and treatment of stress ulcers and GI bleeding aggravated by gastric acid secretion

Dosing Guidelines

0.25-0.5 mg/kg/dose IV q24 hours

Administration

• IV direct over 3-5 minutes
• To make 5 mL of a 2 mg/mL solution:
  1. Draw up 1 mL of the 10 mg/mL injection
  2. Add to 4 mL D5W (Final concentration = 2 mg/mL)
• Maximum concentration for IV direct administration is 4 mg/mL

Adverse Effects

• Agitation, diarrhea
• H2-blocker therapy associated with higher incidence of necrotizing enterocolitis in very low birth-weight infants

Comments

• Reduse dose in renal impairment
• Onset of effect within 1 hour

Supplied As

10 mg/mL vial – must be further diluted prior to IV direct administration

References

Lexi Sick Kids and Lexi Pediatric/Neonates