isoproterenol

isoproterenol

Indication

  • A non-selective beta-adrenergic agonist used to increase cardiac output for cardiovascular shock, bradycardia, heart block and bradyarrhythmias

Dosage Guidelines

  • 0.05– 1 microgram/kg/min
  • Maximum dose of 2 microgram/kg/min

Administration

IV continuous infusion

  • To make 20 mL of a 20 microgram/mL solution
  1. Draw up 2 mL (0.4 mg) of isoproterenol 0.2 mg/mL injection
  2. Add 18 mL of D5W or NS to make a total volume of 20 mL

Adverse Effects

  • Cardiac arrhythmias, tachycardia, hyperglycemia
  • Decreases venous return to the heart, systemic vasodilatation, may cause hypoxemia by increasing intrapulmonary shunt

Comments

  • Tolerance may occur with prolonged use
  • Stop or slow infusion if heart rate is greater than 200 beats per minute as tachycardia may be severe enough to cause congestive heart failure
  • Monitor blood glucose periodically

Supplied As

  • 0.2mg/mL vial
  • 20 microgram/mL IV syringe prepared by Pharmacy

References

LexiComp Sick Kids, LexiComp Pediatric and Neonatal, Neofax