lamivudine (3TC®)
Indication
- In combination with other antiretrovirals, to reduce the risk of HIV vertical transmission from mother to baby
Dosage Guidelines
Gestational age greater than or equal to 32 weeks:
- Birth to 4 weeks of age: 2 mg/kg/dose ORAL q12 hours
- Greater than 4 weeks of age: increase to 4 mg/kg/dose ORAL q12 hours
Gestational age 25 weeks to less than 32 weeks: (based on expert opinion)1
- Birth to 3 weeks of age: 1.5 mg/kg/dose ORAL q12 hours
- 3 to 6 weeks of age: increase to 2 mg/kg/dose ORAL q12 hours
Administration
- ORAL
- May administer with feeds
Adverse Effects
- Nausea, feeding intolerance, diarrhea
- Anemia, thrombocytopenia, neutropenia
- Increase AST, ALT, bilirubin
- Pancreatitis
Comments
- Reduce dosage in patients with renal dysfunction
Supplied As
10 mg/mL oral solution
References
Lexi Sick Kids, Lexi Pediatric and Neonatal, Neofax, Expert Opinion, 2020, Sainte-Justine Hospital, Montreal1