levETIRAcetam (Keppra®)
Indication
- Managment of neonatal seizures
Dosage Guidelines
- Loading Dose: 60 mg/kg/dose ORAL/IV x 1
- Initial maintenance dose 10 mg/kg/dose ORAL/IV q12 hours
- May titrate dose up by 10 mg/kg/day up to effective dose.
- Dose limit: 60 mg/kg/day
Administration
- ORAL
- IV intermittent slow infusion over 15 minutes
Adverse Effects
- CNS depression, fatigue, vomiting
- Increased diastolic blood pressure,
Comments
- If IV route needed initially, transition to oral administration as soon as able
Supplied As
- 100 mg/mL oral liquid
- 15 mg/mL IV syringe prepared by Pharmacy
References
LexiComp Pediatric and Neonatal, LexiComp SickKids