Disclaimer to the Online Edition
This Manual has been designed for use in the NICU at London Health Sciences Centre (LHSC), London, Ontario, Canada, and represents clinical practice at this institution. The information contained within the Manual may not be applicable to other centres. If users of this Manual are not familiar with a drug, it is recommended that the official monograph be consulted before it is prescribed and administered. Any user of this information is advised that the contributors, Editor and LHSC are not responsible for any errors or omissions, and / or any consequences arising from the use of the information in this Manual.
magnesium sulfate
Indication
- The treatment of hypomagnesemia
Dosage Guidelines
25-50 mg magnesium sulfate /kg/dose IV q8-12 hours (2-3 doses may be needed)
(Equivalent to 0.1-0.2 mmol elemental magnesium/kg/dose)
Administration
- IV intermittent slow infusion over 2-4 hours
Adverse Effects
- Cardiovascular: Flushing (dose related), hypotension and vasodilation
- CNS and respiratory depression
- Endocrine and Metabolic: hypermagnesemia (monitor CNS depression and decreased muscle tone)
- Adverse effects are associated with rapid rates of infusion
Comments
- Monitor heart rate, blood pressure and respiratory rate during the infusion
- Monitor serum magnesium levels
- Use with caution in patients with renal impairment
Supplied As
- 40 mg/mL IV syringe supplied by Pharmacy
References
LexiComp Sick Kids, LexiComp Pediatric and Neonatal, CHEO Neonatal Drug Therapy Manual