Disclaimer to the Online Edition
This Manual has been designed for use in the NICU at London Health Sciences Centre (LHSC), London, Ontario, Canada, and represents clinical practice at this institution. The information contained within the Manual may not be applicable to other centres. If users of this Manual are not familiar with a drug, it is recommended that the official monograph be consulted before it is prescribed and administered. Any user of this information is advised that the contributors, Editor and LHSC are not responsible for any errors or omissions, and / or any consequences arising from the use of the information in this Manual
pantoprazole
Indication
- Management of symptomatic gastroesophageal reflux disease (GERD)
Dosage Guidelines
- 1-1.5 mg/kg/dose IV once daily or 0.5-0.75 mg/kg/dose IV q12 hours
Administration
- IV direct over 3-5 minutes
- Reconstitute 40 mg vial with 10 mL 0.9% NaCl to make a 4 mg/mL solution
Adverse Effects
- Generally, well tolerated
- Abdominal pain, cramps, bloating, constipation, diarrhea, vomiting
- Urticaria, prutitus
- Thrombocytopenia, leukopenia
- Thrombophlebitis
- Increased serum triglycerides
Comments
- Routine use is not recommended in preterm neonates
Supplied As
- 40 mg vial for reconstitution
References
LexiComp Sick Kids, LexiComp Pediatric and Neonatal