Disclaimer to the Online Edition
This Manual has been designed for use in the NICU at London Health Sciences Centre (LHSC), London, Ontario, Canada, and represents clinical practice at this institution. The information contained within the Manual may not be applicable to other centres. If users of this Manual are not familiar with a drug, it is recommended that the official monograph be consulted before it is prescribed and administered. Any user of this information is advised that the contributors, Editor and LHSC are not responsible for any errors or omissions, and / or any consequences arising from the use of the information in this Manual
phosphate (as sodium phosphate oral solution)
Indication
- Treatment of metabolic bone disease of prematurity, usually in conjunction with calcium supplements
- Treatment of hypophosphatemia in neonates able to tolerate oral supplements
Dosage Guidelines
- Start at 0.5 mmol elemental phosphate/kg/day
Administration
- ORAL: Mix with feeds
- Do not administer at the same time as calcium supplements
Adverse Effects
- Irritating to gastric mucosa
- Diarrhea
- Hypernatremia
- Hyperphosphatemia, hypocalcemia
Comments
- Advisable to treat concomitant hypocalcemia, if present
- Monitor for response to therapy: serum phosphate, ionized calcium, sodium and alkaline phosphatase (ALP) twice monthly
- Monitor urine and stool output daily (use caution in renal failure)
Supplied As
- Sodium phostphate oral liquid. Each mL of solution contains 4.8 mmol of sodium and 4.2 mmol of phosphate
References
Mount Sinai NICU Medication Manual