phytonadione

Disclaimer to the Online Edition

This Manual has been designed for use in the NICU at London Health Sciences Centre (LHSC), London, Ontario, Canada, and represents clinical practice at this institution. The information contained within the Manual may not be applicable to other centres. If users of this Manual are not familiar with a drug, it is recommended that the official monograph be consulted before it is prescribed and administered. Any user of this information is advised that the contributors, Editor and LHSC are not responsible for any errors or omissions, and / or any consequences arising from the use of the information in this Manual.

phytonadione (Vitamin K1)

Indication

  • Prophylaxis and treatment of vitamin K deficiency bleeding

Dosage Guidelines

  • Prophylaxis: Immediately after birth

  • Less than or equal to 26 weeks gestation: 0.5 mg IV

  • Less than or equal to 1500 grams and greater than 26 weeks gestation: 0.5 mg IM

  • Greater than 1500 grams: 1 mg IM

  • Treatment: 1 mg IM/IV

Administration

  • IM
  • IV: Dilute to 1 mg/mL for infusion over 15 to 30 minutes in D5W or NS.  Protect from light and administer immediately after dilution.

Adverse Effects

  • Rarely: hemolytic anemia, hyperbilirubinemia, and hypersensitivity or anaphylactoid reaction following IV administration

Comments

  • After parenteral administration, blood coagulation factors increase within 1 to 2 hours

Supplied As

  • 2 mg/mL injection (0.5 mL ampoule)
References
  1. LexiComp Sick Kids
  2. Neofax