Tri-vi-Sol®

Disclaimer to the Online Edition

This Manual has been designed for use in the NICU at London Health Sciences Centre (LHSC), London, Ontario, Canada, and represents clinical practice at this institution. The information contained within the Manual may not be applicable to other centres. If users of this Manual are not familiar with a drug, it is recommended that the official monograph be consulted before it is prescribed and administered. Any user of this information is advised that the contributors, Editor and LHSC are not responsible for any errors or omissions, and / or any consequences arising from the use of the information in this Manual.

Tri-vi-Sol®

Indication

  • Vitamin supplement for preterm infants receiving breast milk or formula that does not provide the PRNI (premature recommended nutrient intake)
  • Medical conditions in which vitamin requirements are increased

Dose

  • Start when 50% of full feeds have been reached
    • Less than 1000 g – 0.5 mL BID
    • 1000 – 1500 g – 1 mL daily
    • Greater than 1500 – 2000 g – 0.5 mL daily
  • When full feeds have been reached
    • 1.5 kg or greater – 0.5 mL daily
    • Less than 2 kg at birth and feeding plain EBM – 1 mL daily

Administration

  • ORAL: administer with feeds to avoid GI irritation

Adverse Effects

  • Usually well tolerated at recommended doses

Comments

  • Multivitamins are hyperosmolar and may not be tolerated if infant not yet at 50% full enteral feeds
  • Discontinue multivitamins and trace elements in TPN when Tri-vi-sol is started

Supplied As

  • Oral solution
  • Tri-Vi-Sol® contains per mL: Vitamin A 750 units, Vitamin D 400 units and Vitamin C 30 mg
References
  1. LexiComp Sick Kids
  2. Neofax