Paediatric Epilepsy Research Program
Our epilepsy specialists are constantly looking for innovative and effective ways to treat seizures and epilepsy in children.
Your epileptologists are familiar with the current epilepsy research available and who is eligible to participate. You may be approached to consider enrolling. You will always be given information regarding the study. You or your child (if appropriate) must provide written consent to participate in each study and your participation is voluntary. You may withdraw from the study at any time, but we may ask that you please inform us as to the reason.
During any study you are followed very closely by the Epileptologist(s), Epilepsy R.N, Paediatric Epilepsy Program team and Epilepsy Research Coordinator. Your paediatric epilepsy program staff will maintain the highest level of care and all adhere to global, national, provincial and hospital guidelines and ethics.
London Health Sciences Centre is and will continue to be committed to the highest standards of data privacy and security.
Paediatric epilepsy research areas of focus:
Brain Imaging and Mapping (EEG, MRI, new technologies)
Functional Neuroimaging with Near Infrared Spectroscopy (fNIRS) and fMRI in pediatric epilepsy surgery
Primary Site: London Health Sciences Centre, London ON
International Pediatric Stroke Study (IPSS) is a childhood stroke registry and network made up of dedicated clinicians, scientists and research staff from over 100 institutions in 34 countries.
Primary Site: Hospital for Sick Children, Toronto
Intracranial EEG signal analysis: Quantification of the signal frequency and topographic localization
A study of epilepsy patients with drug resistant epilepsy who undergo or have underwent intracranial electrode implantation including SEEG or subdural electrodes/grids at London Health Sciences Centre.
Primary Site: London Health Sciences Centre, London ON
Longitudinal Brain network connectivity changes using functional and diffusion MRI in pediatric patients with focal epilepsy
A longitudinal prospective observational cohort study in paediatric patients
Primary Site: London Health Sciences Centre, London ON
REMIND: Advancing Refractory Epilepsy Multimodal Imaging in Pediatric Populations
Primary Site: London Health Sciences Centre, London
Epilepsy Treatments (Surgery, VNS, Ketogenic Diet and anti-seizure medications)
A Phase 1/2 Open-label, Multiple-dose, Dose-escalating Clinical Trial of the Safety and Tolerability of GTX-102 in Pediatric Patients With Angelman Syndrome (AS)
This is a Phase 1/2, open-label, multiple-dose, dose-escalating study to evaluate the safety, tolerability, and plasma and CSF concentrations of GTX-102 in pediatric patients with Angelman Syndrome.
Comprehensive Outcomes Registry in Subjects with Epilepsy Treated with Vagus Never Stimulation Therapy
Multicenter global registry of approximately 2000 subjects diagnosed with drug resistant epilepsy and treated with the VNS Therapy System. The study will collect outcomes of subjects treated with VNS Therapy and the purpose of the registry is to evaluate clinical outcome and safety data.
Lorcaserin as Adjunctive Treatment in Participants With Dravet Syndrome
A Multicenter, Double-Blind, Randomized, Placebo-Controlled, Parallel-Group Study With Open-Label Extension Phase of Lorcaserin as Adjunctive Treatment in Participants With Dravet Syndrome
Epilepsy Care (Quality of Life, Comprehensive Epilepsy Clinic, and transitions)
Can overnight pulse oximetry be used to screen for paediatric vagal nerve stimulator induced obstructive sleep apnea: A pilot study.
Primary Site: London Health Sciences Centre, London ON
Breaking Barriers to Health Access in Paediatric Epilepsy: Utilizing Implementation Science Strategies to Deliver a Comprehensive Epilepsy Clinic Model in South & Northwestern Ontario Communities
Primary Site: London Health Sciences Centre, London ON
Shared Decision Making in Paediatrics - Impact of Shared Decision Making Intervention on parental decision making
Primary Site: Children’s Hospital, London Health Sciences Centre
Transition in Epilepsy Care: Evaluating the effectiveness and impact of a long-term transition clinic on recently-transitioned adolescents with epilepsy
Primary Site: Children’s Hospital Eastern Ontario, Ottawa
Understanding Epilepsy and Causes (Genetics, epilepsy syndromes, Drug Resistant Epilepsy, Encephalitis, Metagenomics and autoimmune conditions)
Epilepsy Registry Level 2
The main purpose of the study is to create an epilepsy registry. The registry will include all pediatric epilepsy diagnoses, treatments, and outcomes over the lifespan.
Primary site: Children’s Hospital, London Health Sciences Centre
FCD in neonates: Retrospective review of charts of patients with Focal Cortical Dysplasia type I
Primary Site: London Health Sciences Centre, London ON
Infantile Spasms: Changing Landscape in Treatment of Infantile Spasms; experience from single center retrospective study.
Primary Site: Children’s Hospital, London Health Sciences Centre
PAGE: Investigating the utility of combined Pediatric Autoimmune and Genetic testing in drug-resistant Epilepsy
Primary Site: Children’s Hospital, London Health Sciences Centre
For more information about the Paediatric Epilepsy Research Program contact, Rochelle Sorzano - 519-685-8500 Extension 52448 or rochelle.sorzano@lhsc.on.ca
